GLP-2, human

GLP-2, human is a 33-residue synthetic peptide (H-His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH, trifluoroacetate salt) corresponding to the second glucagon-like peptide encoded in the human proglucagon gene. GLP-2 is co-secreted with GLP-1 from intestinal L cells in response to nutrient ingestion and acts as a potent intestinal trophic factor and mucosal growth agent.

GLP-2 signals through its own receptor (GLP-2R), a class B GPCR expressed predominantly on enteroendocrine cells, subepithelial myofibroblasts, and enteric neurons, and it promotes intestinal mucosal integrity, crypt cell proliferation, and villus height. Burrin and colleagues characterized GLP-2 biology in domestic animal species (pigs, cattle, sheep), providing important comparative context for the peptide's trophic role across species — the sequence is highly conserved and its intestinotropic activity functions consistently in rodent and large-animal models (Burrin DG et al., Domest Anim Endocrinol, 2003, PMID 12586312). Mechanistic studies have shown GLP-2 stimulates Lgr5+ intestinal stem cell S-phase entry, driving crypt proliferation that underpins mucosal regeneration (Chen ME et al., Cell Mol Gastroenterol Hepatol, 2022, PMID 35218981). These biological properties directly motivated the development of teduglutide (Gattex/Revestive), a DPP-IV-resistant GLP-2 analog approved for short bowel syndrome, establishing human GLP-2 as the template for a clinically translated intestinal therapy (Yusta B et al., Endocrinology, 2012, PMID 22535770).

Potential Research Applications: - Intestinal mucosal growth and crypt-villus axis biology (in vitro organoid and in vivo models) - Lgr5+ intestinal stem cell proliferation and regeneration studies - GLP-2R pharmacology and receptor binding assays - Short bowel syndrome, inflammatory bowel disease, and gut injury repair research - Comparative GLP-2 biology across species (pig, bovine, rodent models)

Market Context: Human GLP-2 is currently stocked by a single supplier on this platform (CPC Scientific) at approximately $82.50/mg. Its clinical translation (teduglutide, Gattex) makes this native sequence an important pharmacological reference standard.

Cited Research: Burrin DG et al. (2003). Glucagon-like peptide 2 function in domestic animals. Domest Anim Endocrinol. PMID 12586312. Chen ME et al. (2022). Glucagon-Like Peptide-2 Stimulates S-Phase Entry of Intestinal Lgr5+ Stem Cells. Cell Mol Gastroenterol Hepatol. PMID 35218981. Yusta B et al. (2012). Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice. Endocrinology. PMID 22535770.

For laboratory research use only. Not for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. THIS PRODUCT IS NOT FOR HUMAN CONSUMPTION.