IGF-1 DES 1,3

Insulin Like Growth Factor (IGF)-1 DES is a 67 amino acid residue analogy to native IGF-1, which has been documented as an agent for inducing hyperplasia and stimulating cellular proliferation1. By truncating the original IGF-1 polypeptide – a 70 amino acid residue sequence – to just 67 amino acids, retaining residue numbers 4-70 (hence the synonym ‘IGF-1 [4-70] )2, IGF-1 DES introduces massive enhancements to IGF-1’s biological activity while making marginal improvements to its structural stability, and therefore, residence time, in vivo. Animal studies have demonstrated the ability of IGF-1 DES to bind directly to natural IGF receptors and stimulate new tissue formation, while inhibiting apoptosis (programmed cell death) in existing tissues3. Especially at muscle cell sites, IGF-1 species are noted to enhance amino acid recruitment, augment the synthesis of new proteins while minimizing the digestion of intracellular protein as a fuel source. Instead, fat deposits are used as energy sources while IGF species are biochemically active4. Product Comparison IGF-1 is a key factor in mediating of growth-promoting effects of growth hormone (GH)5. This particular IGF-1 species was developed in order to avoid interaction with IGFBPs (Insulin Like Growth Factor Binding Proteins), which are known to hinder the activity of native IGF-1 over time6. By avoiding this interplay IGF-1 DES is capable of achieving highly active, unimpeded biological activity, which leads to its utility as a fast-acting facilitator of GH-stimulated biochemical activity. IGF-1 DES and IGF-1 LR3 have both been shown to be more active relative to native IGF-1 when it comes to stimulating new cell growth in animal trials. Compared to IGF-1 LR3, IGF-1 DES is considered to be multi-fold more active as a stimulant of acute hypertrophy7. Studies investigating the effects of concurrent IGF-1 species and GH (or GH secretagogue) administration have identified their synergy5 in promoting the development of lean