N-Acetyl Epithalon Amidate

N-Acetyl Epithalon Amidate is a chemically modified analog of the Epithalon (AEDG, Ala-Glu-Asp-Gly) tetrapeptide, carrying an N-terminal acetyl group and a C-terminal amide in place of the free amine and carboxylic acid termini of the parent sequence. N-acetylation and C-amidation are standard peptide-chemistry modifications used to reduce susceptibility to aminopeptidase and carboxypeptidase cleavage, a strategy commonly applied to short peptides to extend their functional half-life in experimental buffer and cell-culture systems.

The unmodified AEDG tetrapeptide (Epithalon/Epitalon) has been studied by Khavinson and colleagues for interactions with chromatin and DNA-binding behavior resembling that of regulatory transcription factors, as well as for extending the replicative capacity of cultured human somatic cells beyond the normal Hayflick-type division limit. Because the acetylated/amidated variant has not been independently tested in those specific published studies, its research profile should be treated as a stability-focused structural analog of Epithalon rather than as having its own dedicated primary literature — researchers comparing the two forms are effectively running a structure-activity/stability comparison against the established AEDG data below.

Potential Research Applications: Peptide stability and enzymatic degradation-resistance research (N-acetyl/C-amide modification strategy) Structure-activity relationship (SAR) studies comparing modified vs. unmodified AEDG tetrapeptide Chromatin-binding and cellular senescence / replicative-limit research models, using the parent Epithalon literature as a reference point

Platform Pricing Data (live, updated continuously): Peptides.SO tracks 4 suppliers offering N-Acetyl Epithalon Amidate; 3 currently report pricing data, ranging $31.00-$171.57 per mg with a median of $90.00/mg — compare current offers on this page rather than relying on outdated third-party price lists.

Cited Research (parent AEDG/Epithalon tetrapeptide — see note above on the acetylated analog's independent research status): Khavinson VKh, Bondarev IE, Butyugov AA. DNA double-helix binds regulatory peptides similarly to transcription factors. Neuro Endocrinol Lett. 2005. PubMed PMID: 15990728. Khavinson VKh, Bondarev IA, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cells. Bull Exp Biol Med. 2004. PubMed PMID: 15455129.

For laboratory research use only. Not for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. THIS PRODUCT IS NOT FOR HUMAN CONSUMPTION.