VIP, guinea pig

Guinea-pig Vasoactive Intestinal Peptide (VIP) is the species variant most extensively used in classic enteric nervous system (ENS) electrophysiology. The isolated guinea-pig ileum, jejunum, and distal colon are the historical model preparations used to characterize VIP's role as a non-adrenergic, non-cholinergic (NANC) inhibitory neurotransmitter controlling smooth-muscle relaxation, and as a secretomotor transmitter released from submucosal neurons that drives intestinal chloride/fluid secretion.

Potential Research Applications: Enteric secretomotor neuron research — guinea-pig jejunum preparations have been used to show VPAC1-receptor-mediated activation of cholinergic secretomotor pathways NANC inhibitory neurotransmission research in gut smooth muscle Submucosal plexus synaptic transmission studies, including VIP-neuron postsynaptic signaling (e.g., mGluR-mediated slow EPSPs onto submucosal VIP neurons) Ex vivo intestinal segment research (Ussing chamber, isolated gut bath preparations)

Platform Pricing Data (live, updated continuously): Peptides.SO currently tracks 1 supplier offering VIP (Guinea Pig) at $93.50/mg. With only a single listed reference point, this is not yet a competitive multi-supplier field — check this page for new listings as coverage grows.

Cited Research: Fung C, Unterweger P, Parry LJ, Bornstein JC, Foong JP. VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum. Am J Physiol Gastrointest Liver Physiol. 2014. PubMed PMID: 24578344. Foong JP, Parry LJ, Bornstein JC. mGluR1 receptors contribute to non-purinergic slow excitatory transmission to submucosal VIP neurons of guinea-pig ileum. Front Neurosci. 2009. PubMed PMID: 20582273.

For laboratory research use only. Not for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. THIS PRODUCT IS NOT FOR HUMAN CONSUMPTION.