[DTrp6]-LH-RH Triptoreline, Ethyl Amide

[D-Trp6]-LH-RH Ethyl Amide (sequence: pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NHEt, supplied as the trifluoroacetate salt) is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH/LH-RH) bearing a D-tryptophan substitution at position 6 and a C-terminal ethylamide modification. Both changes confer resistance to endopeptidase cleavage and substantially increase pituitary GnRH-receptor binding affinity relative to native GnRH. This exact substitution pattern is the defining structure of triptorelin, the active moiety in the FDA-approved GnRH agonist depot products Trelstar and Decapeptyl (indicated for advanced prostate cancer, central precocious puberty, and endometriosis). The ethylamide/TFA-salt form listed here is a synthesis-grade research form, distinct from the clinical acetate/pamoate depot formulations.

Mechanistically, triptorelin analogs act as GnRH receptor superagonists with a biphasic pharmacodynamic profile: an initial "flare" of LH/FSH release during the first days of exposure, followed by receptor downregulation and desensitization over 1-2 weeks of continuous exposure, producing a sustained hypogonadotropic state with suppressed sex-steroid output. This well-characterized desensitization kinetic makes triptorelin analogs a standard reference tool in reproductive endocrinology research.

Potential Research Applications: - GnRH receptor pharmacology and agonist-induced desensitization kinetics - Hypothalamic-pituitary-gonadal (HPG) axis suppression models - Sex-steroid-dependent tumor and precocious puberty research models - Comparative GnRH agonist/antagonist reproductive endocrinology studies - Pituitary cell culture and perifusion assays of pulsatile LH/FSH secretion

Market Context: This specific ethylamide research form is currently listed by 1 supplier on this platform (CPC Scientific, approximately $27.50/mg), reflecting its niche status as a synthesis-grade variant rather than the more commonly stocked triptorelin acetate form. Researchers comparing broader supplier pricing should also review the platform's GnRH-Triptorelin listing, which aggregates additional suppliers carrying the acetate-salt form.

Cited Research: Cirkel U, Ochs H (1995). A randomized, comparative trial of triptorelin depot (D-Trp6-LHRH) and danazol in the treatment of endometriosis. Eur J Obstet Gynecol Reprod Biol. PMID 7781864. Torres-Aleman I, Fernandez M (1987). Effect of [D-Trp6]LHRH infusion on prolactin secretion by perifused rat pituitary cells. Regul Pept. PMID 2957725.

For laboratory research only. Not for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. THIS PRODUCT IS NOT FOR HUMAN CONSUMPTION.