GLP-1 (7-36), amide, chicken, common turkey

GLP-1 (7-36), amide, chicken, common turkey is a 30-residue synthetic peptide (H-His-Ala-Glu-Gly-Thr-Tyr-Thr-Ser-Asp-Ile-Thr-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Asn-Gly-Arg-NH2, trifluoroacetate salt) representing the avian ortholog of the bioactive amidated GLP-1 form from Gallus gallus (chicken) and Meleagris gallopavo (common turkey). The sequence differs from the mammalian GLP-1(7-36)-NH2 at positions 11 (Ser→Tyr) and 22 (Lys→Asn), with an identical C-terminal Arg-NH2 amidation.

GLP-1 and its receptor are highly conserved across vertebrates, and avian GLP-1 has been studied both to understand avian glucose homeostasis and as a structural comparator for determining which amino acid positions define GLP-1R binding affinity. The GLP-1 receptor is expressed in pancreatic D cells and other tissues in chickens and other avian species; Watanabe and colleagues characterized GLP-1R expression histologically in chicken pancreatic D cells and showed it is present in White Leghorns (Watanabe T et al., Cell Tissue Res, 2014, PMID 24797838), with a follow-up comparative study extending GLP-1R localization to Northern Bobwhite and Common Ostrich pancreatic tissue (Watanabe T et al., J Poult Sci, 2018, PMID 32055175). These findings confirm that avian GLP-1R–peptide signaling is operative, making this peptide useful for comparing avian versus mammalian GLP-1R pharmacology and for understanding species differences in glucose regulation.

Potential Research Applications: - Comparative GLP-1R pharmacology: avian vs. mammalian receptor binding and activation - Avian glucose homeostasis and insulin secretion research (in vitro and ex vivo pancreatic preparations) - Structure-activity relationship mapping at residues 11 and 22 of GLP-1 (positions that differ between avian and mammalian sequences) - Species-ortholog comparisons for GLP-1R agonist drug design and selectivity profiling

Market Context: This avian-specific GLP-1 peptide is currently stocked by a single supplier on this platform (CPC Scientific) at approximately $82.50/mg, consistent with its status as a specialized comparative pharmacology reagent.

Cited Research: Watanabe T et al. (2014). Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas. Cell Tissue Res. PMID 24797838. Watanabe T et al. (2018). Glucagon-like Peptide-1 Receptor Expression in the Pancreatic D Cells of Three Avian Species; White Leghorn Chickens, Northern Bobwhites, and Common Ostriches. J Poult Sci. PMID 32055175.

For laboratory research use only. Not for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. THIS PRODUCT IS NOT FOR HUMAN CONSUMPTION.