GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat)

GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat) is a 31-residue synthetic peptide (H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH) representing the biologically active form of glucagon-like peptide-1 that terminates in a free glycine at position 37. Identical sequence across humans, cattle, guinea pigs, mice, and rats, making this preparation a species-agnostic reference standard for comparative and cross-species GLP-1 receptor pharmacology.

Glucagon-like peptide-1 is encoded within the proglucagon gene and processed from proglucagon in intestinal L cells and brainstem neurons. Mojsov and colleagues were first to demonstrate that the GLP-1(7-37) sequence is the primary insulinotropic component co-encoded in the glucagon gene — showing that this peptide potently stimulates insulin release from the perfused rat pancreas in a glucose-dependent manner, identifying it as a true incretin hormone (Mojsov S et al., J Clin Invest, 1987, PMID 3543057). GLP-1(7-37) signals through the GLP-1 receptor (GLP-1R), a class B GPCR expressed on pancreatic beta cells, and its cloning and expression cloning by Thorens established the molecular basis for the peptide's insulinotropic activity (Thorens B, Proc Natl Acad Sci USA, 1992, PMID 1326760). In most species GLP-1(7-37) circulates alongside the amidated form GLP-1(7-36)-NH2, with both forms carrying comparable potency at the GLP-1R; neither form discriminates between human, bovine, rodent, or guinea pig GLP-1R orthologs at the peptide sequence level.

Potential Research Applications: - Reference standard and comparator for GLP-1R agonism potency assays across species - Cross-species beta-cell secretion studies (rat, mouse, guinea pig, bovine pancreatic preparations) - Structure-activity relationship research on GLP-1 N- and C-terminus modifications - Receptor binding competition assays for GLP-1R characterization in native tissue

Market Context: This preparation is currently stocked by a single supplier on this platform (CPC Scientific) at approximately $104.50/mg, consistent with its status as a specialized incretin pharmacology research reagent.

Cited Research: Mojsov S et al. (1987). Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. PMID 3543057. Thorens B (1992). Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA. PMID 1326760.

For laboratory research use only. Not for human or veterinary use, diagnosis, treatment, cure, or prevention of any disease. THIS PRODUCT IS NOT FOR HUMAN CONSUMPTION.